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Endep
contains the active ingredient amitriptyline hydrochloride
CONSUMER MEDICINE INFORMATION
What is in this leaflet
This leaflet answers some common questions about Endep. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking Endep against the benefits they expect it will have for you. If you have any concerns about taking this medicine, talk to your doctor or pharmacist. Please read this leaflet carefully and keep it with your medicine. You may need to read it again.

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What Endep is used for Endep is used to treat depression. Endep 10 mg and Endep 25 mg tablets can be used at any stage in the treatment of depression. However, the highest strength Endep 50 mg, is approved only for the maintenance treatment of depression (after your symptoms have improved). Endep belongs to a group of medicines called tricyclic antidepressants (TCAs). TCA medicines work by correcting the imbalance of certain chemicals in the brain. These chemicals, called amines, are involved in controlling mood. By correcting this imbalance, TCAs can help relieve the symptoms of depression. Endep can also be used to treat bed-wetting, provided that there is no physical cause for the problem (eg. problems with the bladder). Ask your doctor if you have any questions about why Endep has been prescribed for you.
Your doctor may have prescribed Endep for another reason.
Endep is not approved for use in children and adolescents below 18 years of age for the treatment of depression.
The safe use and effectiveness of Endep in treating the above condition, for this age group, has not been established.
Endep is available only with a doctor's prescription.
Before you take Endep
When you must not take it
Do not take Endep if you are allergic to medicines containing amitriptyline (e.g. Tryptanol) or any of the ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include skin rash, itching or hives; swelling of the face or tongue which may cause difficulty swallowing or breathing; increased sensitivity of the skin to the sun.
Do not take Endep if you have recently had a heart attack.
Taking Endep could make your condition worse.
Do not take Endep if you are taking, or have taken within the last 14 days another medicine for depression called a monoamine oxidase inhibitor (MAOI).
Taking Endep with a MAOI or taking it too soon after stopping a MAOI may cause a serious reaction with a sudden increase in body temperature, extremely high blood pressure and severe convulsions. Your doctor will tell you when it is safe to start taking Endep after stopping the MAOI.
Ask your doctor or pharmacist if you are unsure if you are taking, or have been taking a MAOI.
MAOIs are medicines used to treat depression and symptoms of Parkinson's disease. Examples of MAOIs are phenelzine (Nardil), tranylcypromine (Parnate), moclobemide (eg. Aurorix, Arima) and selegiline (Eldepryl, Selgene).
Do not take Endep if you are taking cisapride (Prepulsid), a medicine used to treat stomach reflux.
Combining Endep with cisapride may cause serious side effects such as an abnormal heart rhythm.
Do not take Endep if you are breastfeeding.
Endep passes into breast milk and may harm your baby.
Do not take Endep if the expiry date (EXP) printed on the pack has passed.
If you take this medicine after the expiry date has passed, it may not work as well.

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DRUG INTERACTIONS: Monoamine oxidase inhibitors (for example, tranylcypromine) and tricyclic antidepressants (for example, amitriptyline (Endep)] may increase the effect of salmeterol on the heart and blood pressure. Since Advair Diskus contains salmeterol, it should not be used with or within two weeks of discontinuing monoamine oxidase inhibitors or tricyclic antidepressants.

PREGNANCY: Adequate studies of fluticasone or inhaled salmeterol during pregnancy have not been done. Fluticasone use during pregnancy should be avoided unless the potential benefit justifies the potential but unknown risk to the fetus. In some, but not all, pregnant animal models exposure to very high doses of oral salmeterol has led to offspring with birth defects. The concentrations of salmeterol in the blood after these very high doses, however, were much higher than the concentrations observed after inhalation. Salmeterol inhalation should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

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NURSING MOTHERS: It is not known if fluticasone propionate is secreted in breast milk. Other medications in the same class as fluticasone propionate are secreted into breast milk, but it is not known whether the small amounts that may appear in the milk have effects on nursing infants. In rats, salmeterol is excreted in milk. Therefore, caution should be exercised when salmeterol is administered to nursing women.

SIDE EFFECTS: Upper respiratory tract infections occur in 20%-25% of patients using Advair Diskus. Headaches occur in about 1 in 8 patients who use it. Other potential adverse events include nausea, vomiting, diarrhea, mouth or throat candidiasis, and musculoskeletal pain. Use of long acting agents like salmeterol, an active ingredient in Advair Diskus, may increase the risk of asthma-related death. Therefore Advair Diskus should only be used in patients uncontrolled by other agents.

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